The Church was formed and founded on Pentecost in Jerusalem. Followers of Jesus as the Messiah (Ha Maschiach), trace the origin of becoming known to the world as 'Christians' to the community founded in Antioch: "Then departed Barnabas to Tarsus, for to seek Saul: and when he found him he brought him to Antioch." For a whole year they met with the church and taught large numbers. The disciples, whose origins began in the dispersion resulting from persecution in Jerusalem, were "first called Christians at Antioch." Known by a variety of names, including "Followers of the Way." Later recognized by the Apostles in Jerusalem, one of its leading members was Barnabas, who was sent to organize the new church (see Acts 11:19-26) (see Early centers of Christianity). It later became the Patriarchate of Antioch as one of the five major patriarchates – that is the Pentarchy – Pentarchy is a model of Church organization historically championed in the Eastern Orthodox Church. It found its fullest expression in the laws of Emperor Justinian I of the Byzantine Empire.
According to Acts 11:19-26, the Christian community at Antioch began when Christians who were scattered from Jerusalem because of persecution fled to Antioch. They were joined by Christians from Cyprus and Cyrene who migrated to Antioch. It was in Antioch that the followers of Jesus were first referred to as Christians.
A main point of interest, however, is connected with the progress of Christianity among the non-Jewish believers. Tradition holds that the first Acts 11:20-21, where it is recorded that the disciples of Jesus Christ were first called Christians (Acts 11:26). It was from Antioch that St. Paul started on his missionary journeys.
In the dispersion of the original Church at Jerusalem, during the troubles ensuing on the bold action of Stephen, certain Cypriote and Cyrenaic Jews, who had been brought up in Greek communities and who had different perspectives on the world than the Palestinian Jews , came to Antioch. There they made the "innovation" of addressing not merely Jews but also Greeks (see Godfearers for the historical background). We may understand here (1) that the words used imply successful preaching and the admission of Greeks to the Christian congregation, and (2) that such an innovation took place by slow degrees, and began in the synagogue, where Greek proselytes heard the word.
Antioch is intimately connected with the early history of the gospel. It was the great central point from where missionaries to the Gentiles were sent (presumably following the Great Commission). It was the birthplace of the famous Christian father Chrysostom, who died A.D. 407.
Nicolas the deacon of the Seven Deacons was a proselyte of Antioch. The Christians dispersed by Stephen's martyrdom preached at Antioch to idolatrous Greeks, not "Grecians" or Greek-speaking Jews, according to the Acts 11:20-26, whence a church having been formed under Barnabas and Paul's care. From Antioch their charity was sent by the hands of Barnabas and Saul to the brethren at Jerusalem suffering in the famine.
Paul began his ministry systematically here. At Antioch Galatians 2:11-12, the Acts 14:26. He began, after the Acts 15:36,18:22-23. His third journey also began there. Ignatius was subsequently bishop there for forty years, down to his martyrdom A. D. 107.
The seat of the patriarchate was formerly Antioch, in what is now Turkey. However, in the 15th century, it was moved to Syria in response to the Ottoman invasion.
Some Grecian "ancient synagogal" priestly rites and hymns have survived partially to the present, notably in the distinct church services of the Melkite and Greek Orthodox communities of the Hatay Province of Southern Turkey, Syria, Lebanon and Northern Israel. Members of these communities still call themselves Rûm which literally means "Eastern Roman" or Byzantine in Turkish, Persian and Arabic. The term "Rum" is used in preference to "Ionani" which means Greek or "Ionian"